Journal of Andrology Testis Workshop 2009
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Published-Ahead-of-Print July 3, 2009, DOI:10.2164/jandrol.109.007898

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Arun Khattri
Rajeev Kumar Pandey
Lalji Singh
K Thangaraj
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APOB Gene Signal Peptide Deletion Polymorphism Is Not Associated with Infertility in Indian Men

Arun Khattri , Rajeev Kumar Pandey , Nalini J Gupta , Baidyanath Chakravarty , Mamta Deenadayal , Lalji Singh , and K Thangaraj *

* To whom correspondence should be addressed. E-mail: thangs{at}ccmb.res.in.

The apolipoprotein B (APOB) plays a key role in lipoprotein metabolism and plasma lipid transport. It has been shown that about two-thirds of male mice heterozygous for ApoB were infertile. Moreover, a three codon deletion polymorphism (rs11279109) in the signal peptide region of the APOB gene has been shown to be a risk factor for infertility in Slovenian men, but its association with infertility in Indian men has not been evaluated to date. Hence, in the present study, we have genotyped this polymorphism in 545 Indian men, including 294 infertile and 251 fertile men. Our results show that the distribution of this deletion polymorphism was consistent with Hardy-Weinberg equilibrium in both infertile and fertile men. No statistically significant difference was observed in the distribution of the APOB signal peptide deletion polymorphism between infertile and fertile men ({chi}2 = 0.156, P = 0.925 for genotypes and {chi}2 = 0.015, P = 0.903 for alleles). Moreover, no significant difference was observed when infertile and fertile men were categorized on the basis of presence (D/D+D/W genotypes) or absence (W/W genotypes) of deletion (OR = 0.955, 95%CI = 0.644-01.418, P = 0.820). Our study concludes that the APOB gene deletion polymorphism is not a risk factor for the development of infertility in Indian men.


Key words: Infertility • Spermatogenesis • apolipoprotein B • deletion polymorphism






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