Journal of Andrology Testis Workshop 2009
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Published-Ahead-of-Print May 14, 2009, DOI:10.2164/jandrol.108.007377

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Longer (TA)n Repeat but not A49T and V89L Polymorphisms in SRD5A2 Gene May Confer Prostate Cancer Risk in South Indian Men

Singh Rajender , Krishnaswamy Vijayalakshmi , Singh Pooja , Sakhamuri Madhavi , Solomon FD Paul , V Vettriselvi , Sunil Shroff , Lalji Singh , and Kumarasamy Thangaraj *

* To whom correspondence should be addressed. E-mail: thangs{at}ccmb.res.in.

Testosterone is converted to 5 {alpha}-dihydrotestosterone by 5 {alpha}-resudcatse enzyme, which is encoded by SRD5A2 gene. 5 {alpha}-dihydrotestosterone (DHT) is the main androgen which is responsible for prostate growth. We have analyzed complete coding region of SRD5A2 gene in 87 histologically confirmed prostate cancer (PC) patients, 40 benign prostatic hyperplasia (BPH) cases and 96 control samples from southern parts of India. The study revealed A49T site to be monomorphic, V89L site to be highly polymorphic and two allelic forms of (TA)n. There was no significant difference in the distribution of V89L alleles between PC cases and controls, however (TA)9 alleles were different between the two groups. BPH cases exhibited alleles similar to controls at all polymorphic sites. The sequencing of the whole coding region did not reveal any other known or novel polymorphism in this gene. Our study emphasizes that (TA)9 allele may confer certain PC risk but A49T and V89L polymorphisms does not confer PC risk in south Indian men.


Key words: Hormone • Infertility • Prostate • Reproductive Genetics • Spermatogenesis






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