Journal of Andrology
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Published-Ahead-of-Print February 19, 2009, DOI:10.2164/jandrol.108.007138

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Is Penile Length a Factor in Treatment of Erectile Dysfunction with PDE-5 Inhibitor?

Murat Savas *, Ercan Yeni , Halil Ciftci , Ufuk Topal , Mazhar Utangac , and Ayhan Verit

* To whom correspondence should be addressed. E-mail: mrtsvs{at}yahoo.com.

Erectile dysfunction (ED) is prevalent among men and several factors can contribute to the failure of erectile dysfunction treatment based on PDE-5 inhibitors. The aim of this study was to investigate the impact of penile size in treatment of ED with PDE-5 inhibitor (tadalafil 20 mg). We prospectively scrutinized and enrolled to the present study 42 consecutive patients with ED. All the measurements of penile length in fully stretched states and the erectile function domain of the International Index of Erectile Function (IIEF-EF) scores were recorded by the same physician (MS). Patients were divided into three groups according to stretched penile length as small (<25th percentiles), normal (25-75 percentiles) and large (>75th percentiles). Mean IIEF-EF scores were recorded before and after treatment period. Patients received tadalafil 20 mg, taken on demand, minimum of 6 times. The mean stretched penile length was 13.44 ± 2.4 (range 9.50-18.00) cm. Overall mean IIEF-EF domain scores were 11.90 ± 4.78 and 18.67 ± 6.70, for the before and after treatment period, respectively. Although PDE-5 inhibitor treatment significantly improved all domains of the IIEF-EF scores (p<0.05), no statistically significant difference was found among the three groups according to mean IIEF-EF domain scores before and after treatment (p>0.05). We conclude that penile size is not a factor in treatment ED patients with a PDE-5 inhibitor.


Key words: Erectile Dysfunction • Penis • IEEF • PDE-5 • penile length






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