Journal of Andrology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published-Ahead-of-Print April 2, 2009, DOI:10.2164/jandrol.108.006999

This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
30/4/352    most recent
Author Manuscript (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Musicki, B.
Right arrow Articles by Bivalacqua, T. J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Musicki, B.
Right arrow Articles by Bivalacqua, T. J

Post-Translational Modification of Constitutive Nitric Oxide Synthase in the Penis

Biljana Musicki , Ashley E Ross , Hunter C Champion , Arthur L. Burnett , and Trinity J Bivalacqua *

* To whom correspondence should be addressed. E-mail: tbivala1{at}jhmi.edu.

Erectile dysfunction (ED) is a common men's health problem characterized by the consistent inability to sustain an erection sufficient for sexual intercourse. Basic science research on erectile physiology has been devoted to investigating the pathogenesis of ED and has led to the conclusion that ED is predominately a disease of vascular origin and/or neurogenic dysfunction. The constitutive forms of nitric oxide synthase [NOS; endothelial NOS (eNOS) and neuronal NOS (nNOS)] are important enzymes involved in the production of nitric oxide (NO) and thus regulate penile vascular homeostasis. Given the impact of endothelial- and neuronal-derived NO in penile vascular biology, a great deal of research over the past decade has focused on the role of NO synthesis from the endothelium and nitrergic nerve terminal in normal erectile physiology as well as in disease states. Loss of the functional integrity of the endothelium and subsequent endothelial dysfunction plays an integral role in the occurrence of ED. Therefore, molecular mechanisms involved in dysregulation of these NOS isoforms in the development of ED are essential to discovering the pathogenesis of ED in various disease states. This communication reviews the role of eNOS and nNOS in erectile physiology and discusses the alterations in eNOS and nNOS via post-translation modification in various vascular diseases of the penis.


Key words: Erectile Dysfunction • Penis • endothelium • nitric oxide • nitric oxide synthase




This article has been cited by other articles:


Home page
 Pharmacol. Rev.Home page
K.- E. Andersson
Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction
Pharmacol. Rev., December 1, 2011; 63(4): 811 - 859.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
S. H. Francis, J. L. Busch, and J. D. Corbin
cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action
Pharmacol. Rev., September 1, 2010; 62(3): 525 - 563.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2009 by The American Society of Andrology.