Journal of Andrology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published-Ahead-of-Print December 4, 2008, DOI:10.2164/jandrol.108.006783

This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
30/3/233    most recent
Author Manuscript (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Author home page(s):
Eva Oracova
Petra Musilova
Olga Kopecna
Roman Rybar
Miluse Vozdova
Katerina Vesela
Jiri Rubes
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Oracova, E.
Right arrow Articles by Rubes, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oracova, E.
Right arrow Articles by Rubes, J.

Sperm and Embryo Analysis in a Carrier of Supernumerary inv dup(15) Marker Chromosome

Eva Oracova , Petra Musilova , Olga Kopecna , Roman Rybar , Miluse Vozdova , Katerina Vesela , and Jiri Rubes *

* To whom correspondence should be addressed. E-mail: rubes{at}vri.cz.

We identified a small, paternally inherited supernumerary marker chromosome inv dup(15), in a phenotypically normal and normozoospermic male from a couple with reproductive problems. Sperm analysis by fluorescence in situ hybridization (FISH) showed that the marker was present in 26% of sperm nuclei. The disomy 15 was ten times higher than in normal control donors. FISH analysis for aneuploidies of the other chromosomes showed an increase in non-disjunction of chromosome 21. We also examined twenty-four embryos by preimplantation genetic diagnosis and ten (41.7%) embryos contained the marker. This report provides information about inheritance of inv dup(15) from a male carrier.


Key words: Assisted reproduction • Reproductive Genetics • Sperm • FISH • chromosome 15






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2008 by The American Society of Andrology.