Journal of Andrology
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Published-Ahead-of-Print September 4, 2008, DOI:10.2164/jandrol.108.006015

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The Clinical Implications of the Emerging Link Between Hypogonadism & Metabolic Syndrome

André T. Guay *

* To whom correspondence should be addressed. E-mail: andre.t.guay{at}lahey.org.

The metabolic syndrome (MS) is comprised of various medical conditions that confer increased risk of diabetes and cardiovascular disease. The pathophysiological components of MS include glucose abnormality, obesity or increased waist circumference, blood pressure, and hyperlipidemia. There is an increased risk of hypogonadism in men with the metabolic syndrome and its individual components, including insulin resistance, considered by some to be at the core of metabolic syndrome. Hypogonadism may even predict the metabolic syndrome. These factors are interwoven and impact overall health including sexual dysfunction. One interesting and important question is whether treating hypogonadism with testosterone replacement will ameliorate the pathological components of the metabolic syndrome.


Key words: Androgen • Erectile Dysfunction • Hormone • hypogonadism • metabolic syndrome • testosterone




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A. Sonmez, C. Haymana, E. Bolu, A. Aydogdu, S. Tapan, M. Serdar, B. Altun, C. Barcin, A. Taslipinar, C. Meric, et al.
Metabolic syndrome and the effect of testosterone treatment in young men with congenital hypogonadotropic hypogonadism
Eur. J. Endocrinol., May 1, 2011; 164(5): 759 - 764.
[Abstract] [Full Text] [PDF]


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