Journal of Andrology Testis Workshop 2009
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Published-Ahead-of-Print October 16, 2008, DOI:10.2164/jandrol.108.005694

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Hormonal Treatment of Male Infertility: Promises and Pitfalls

Dama Madhukar and Singh Rajender *

* To whom correspondence should be addressed. E-mail: rajender_singh{at}cdri.res.in.

Approximately 50% of the infertility issues are due to male factors. A number of different factors may result in similar reduction of sperm count or motility, and affect sperm morphology. It is not only the etiology of male infertility which is difficult to understand, but it is equally challenging to treat male infertility, due to its etiological heterogeneity. Because of complex and incomplete knowledge of the underlying causes, most of the infertile men are described as idiopathic oligozoospermic and/or asthenozoospermic. Different hormonal treatments have been attempted aiming to improve mainly endogenous FSH and/ or androgen levels, and subsequent spermatogenesis. Various studies have tried to treat infertility through natural pregnancies, increased sperm retrieval for in vitro fertilization techniques, or treat spermatozoa in vitro to improve its fertilizing potential. The present review focuses on all the aspects of male infertility treatment by hormone supplementation.


Key words: Infertility • Spermatogenesis • Hormonal treatment • in vitro fertilization • oligozoospermia






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