| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
* To whom correspondence should be addressed. E-mail: ttt{at}virginia.edu.
Oxidative stress results from the production of oxygen radicals in excess of the antioxidant capacity of the stressed tissue. Many conditions or events associated with male infertility are inducers of oxidative stress. X-irradiation, for example, or exposure to environmental toxicants and the physical conditions of varicocele and cryptorchidism have been demonstrated to increase testicular oxidative stress, which leads to an increase in germ cell apoptosis and subsequent hypospermatogenesis. Such stress conditions can cause changes in the dynamics of testicular microvascular blood blow, endocrine signaling, and germ cell apoptosis. Testicular oxidative stress appears to be a common feature in much of what underlies male infertility, which suggests there may be benefits to developing better antioxidant therapies for relevant cases of hypospermatogenesis.
Key words: Infertility
Reactive Oxygen
Testis
This article has been cited by other articles:
![]() |
C. Schell, M. Albrecht, S. Spillner, C. Mayer, L. Kunz, F. M. Kohn, U. Schwarzer, and A. Mayerhofer 15-Deoxy-{Delta}12-14-Prostaglandin-J2 Induces Hypertrophy and Loss of Contractility in Human Testicular Peritubular Cells: Implications for Human Male Fertility Endocrinology, March 1, 2010; 151(3): 1257 - 1268. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. A. Sartorius and E. Nieschlag Paternal age and reproduction Hum. Reprod. Update, January 1, 2010; 16(1): 65 - 79. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Paul, S. Teng, and P. T.K. Saunders A Single, Mild, Transient Scrotal Heat Stress Causes Hypoxia and Oxidative Stress in Mouse Testes, Which Induces Germ Cell Death Biol Reprod, May 1, 2009; 80(5): 913 - 919. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Jia, J. Castellanos, C. Wang, I. Sinha-Hikim, Y. Lue, R. S. Swerdloff, and A. P. Sinha-Hikim Mitogen-Activated Protein Kinase Signaling in Male Germ Cell Apoptosis in the Rat Biol Reprod, April 1, 2009; 80(4): 771 - 780. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |