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Published-Ahead-of-Print June 20, 2008, DOI:10.2164/jandrol.108.005090

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The DNA/RNA-Binding Protein, Translin, Binds MicroRNA122a and Increases Its In Vivo Stability

Zuoren Yu and Norman B. Hecht *

* To whom correspondence should be addressed. E-mail: nhecht{at}mail.med.upenn.edu.

Translin (TSN), also known as Testis-Brain RNA-binding protein (TB-RBP), is proposed to bind to breakpoint junctions at chromosomal translocations in the nucleus and to specific RNAs in the cytoplasm. In germ cells of the mouse testis, it recognizes target mRNAs transcribed by the transcription factor CREM-tau in spermatids, specific meiotically expressed mRNAs, and a non-coding RNA that encodes piRNAs. Here we show that TSN also binds to the microRNA, miR-122a. MiR-122a is expressed in late stage germ cells and is complementary to a sequence in the 3' UTR of the transition protein 2 mRNA. The binding of TSN to miR-122a increases its in vivo stability suggesting an additional post-transcriptional function for Translin.


Key words: Reproductive Genetics • Reproductive Tract • Spermatogenesis • Testis • RNA stabilization • RNA-binding proteins • RNA-protein interactions • microRNAs






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