Journal of Andrology
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Published-Ahead-of-Print July 17, 2008, DOI:10.2164/jandrol.107.004838

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Effects of Testosterone on Antioxidant Systems in Male Secondary Hypogonadism

Antonio Mancini *, Erika Leone , Roberto Festa , Giuseppe Grande , Andrea Silvestrini , Laura De Marinis , Alfredo Pontecorvi , Giulio Maira , Littarru Gianpaolo , and Elisabetta Meucci

* To whom correspondence should be addressed. E-mail: mancini.giac{at}mclink.it.

Oxidative stress is involved both in metabolic syndrome and male infertility. Hypogonadism is also associated with increased risk for cardiovascular disease. To investigate the role of gonadal steroids in systemic antioxidants regulation, we determined plasma CoenzymeQ10 (CoQ10) and Total Antioxidant Capacity (TAC) in post-surgical hypopituitaric patients. Twenty-six patients, aged 28-55 ys, were studied 6-12 months after operation. CoQ10 levels were measured by HPLC; TAC by spectroscopy using the system mioglobin-H2O2, which, interacting with the chromogen 2,2I-azinobis-(3-ethylbenzothiazoline-6-sulphonate), generates a radical after a latency time (LAG) that is proportional to antioxidant content. Sixteen patients presented low testosterone values; in 10 patients hypogonadism was isolated, while in 6 patients also hypothyroidism was present. CoQ10 levels were significantly lower in isolated hypogonadism than in normogonadism. Testosterone treatment, performed in those patients with isolated hypogonadism, induced a significant enhancement both in CoQ10 level and LAG. CoQ10 and LAG values significantly correlated, suggesting an inter-relationship between different antioxidants. Our data suggest that hypogonadism could represent a condition of oxidative stress, in turn related with augmented cardiovascular risk.


Key words: Androgen • Hormone • Reactive Oxygen • Coenzyme Q10 • Total antioxidant capacity




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