Journal of Andrology
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Published-Ahead-of-Print April 3, 2008, DOI:10.2164/jandrol.107.004754

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Intrauterine Insemination with Double Ejaculate Compared to Single Ejaculate in Male Factor Infertility: A Pilot Study

Tansu Küçük *, Eran Sözen , and Burcu Buluc

* To whom correspondence should be addressed. E-mail: tansukucuk{at}gmail.com.

Our objective was to compare the efficiency of using double ejaculate to single ejaculate for intrauterine insemination in male subfertility. Eligibility for the study was a total motile sperm count between 1 and 5 x 106 on post-wash sperm analysis. Thirty-nine couples were randomized to the study group, while other 50 couples were randomized to serve as the control group. Males in the study group were asked to produce second semen sample within 2 hours from the first sample on the day of insemination. Data of 89 IUI cycles was presented in the current report. There was no statistically significant difference between two groups in clinical and laboratory characteristics. In the study group, the mean total motile sperm count in the first sample was 3.83 ± 0.85 x 106 SD (range 1.1-4.9) while it was 3.99 ± 0.72 x 106 SD (range 0.9-4.4), in the control group. The mean total motile sperm count in the second sample was 3.52 ± 1.46 x 106 SD (range 0.9-3.7) in the study group. The mean total motile sperm count in the final inseminate was 7.35 ± 1.90 x 106 SD (range 2.9-10.6) in the study group. The difference in TMS counts between the study and the control group was statistically significant (P < 0.001). There were 6 pregnancies in the study group, providing a pregnancy rate of 15.3%, whereas there was 5 pregnancies in the control group (10%) (P = 0.44). Although not increasing the likelihood pregnancy rate significantly, obtaining a second semen sample when the motile sperm yield of the first semen sample was 1-5 million, significantly increases total motile sperm count in final inseminate.


Key words: Assisted reproduction • Fertilization • Infertility • double ejaculate • intrauterine insemination






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