Journal of Andrology
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Published-Ahead-of-Print July 31, 2008, DOI:10.2164/jandrol.107.004309

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Genetic Screening (Chromosomal Abnormalities, Y Chromosome Deletions and Androgen Receptor CAG Repeat Length) in Infertile Mexican Men

Sandra Guadalpue Martínez-Garza *, Mayra Celina Gallegos-Rivas , Marcos Vargas-Maciel , Juan Manuel Rubio-Rubio , Mario Espinosa de los Monteros-Rodríguez , Claudia González-Ortega , Patricia Cancino-Villarreal , Luis G. Vazquez de Lara , and Antonio Martín Gutierrez-Gutierrez

* To whom correspondence should be addressed. E-mail: samartin30{at}yahoo.com.

We analyzed chromosomal abnormalities, Y-chromosome deletions, androgen receptor CAG repeat length, and its association with defective spermatogenesis in infertile Mexican men. Eighty-two infertile patients and 40 controls were screened for karyotypic abnormalities, Y-chromome microdeletions, and CAG repeats. Nine infertile males (11%) carried chromosomic abnormalities and 10 (12.2%) presented Y chromosome microdeletions. Mean CAG repeat length was 21.6 and 20.88 base pairs in idiopathic infertile males and controls, respectively. Chromosomal aberrations and Y-chromosomal microdeletions are related to male infertility in our population. Expansion of the CAG repeat segments of the androgen receptor is not correlated with male idiopathic infertility.


Key words: karyotype • microdeletion • oligospermia • trinucleotide repeat.




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