Journal of Andrology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published-Ahead-of-Print October 3, 2007, DOI:10.2164/jandrol.107.002774

This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
29/1/102    most recent
Author Manuscript (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Saad, F.
Right arrow Articles by Yassin, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Saad, F.
Right arrow Articles by Yassin, A.

A Dose Response Study of Testosterone on Sexual Dysfunction and on Features of the Metabolic Syndrome Using Testosterone Gel and Parenteral Testosterone Undecanoate

Farid Saad *, Louis J Gooren , Ahmad Haider , and Aksam Yassin

* To whom correspondence should be addressed. E-mail: farid.saad{at}bayerhealthcare.com.

Objective: To study the dose responses of testosterone (T) treatment on sexual dysfunction and the metabolic syndrome two cohorts of elderly men with late onset hypogonadism were followed over 9 months. Patients & methods: Group 1 (28 men; mean age 61 yrs; mean T 2.07 ± 0.50 ng/ml) received the long acting T undecanoate (1000 mg. Group 2 (27 men, mean age 60 yrs, mean T 2.24 ± 0.41) received T gel (50 mg/day) for 9 months. Results: (* statistical significance) With T gel plasma T rose from 2.24 ± 0.41 to 2.95 ± 0.52* at 3 mo, to 3.49 ± 0.89* at 6 mo, to 3.80 ± 0.73 at 9 mo (T at 6 mo* compared to T at 3 mo). With TU plasma T rose from 2.08 ± 0.56 to 4.81 ± 0.83* at 3 mo, to 5.29 ± 0.91 at 6 mo, to 5.40 ± 0.77 at 9 mo. With TU administration plasma T was *higher than with T gel. With TU there was a larger improvement of sexual symptoms (International Index of Erectile Function) and on parameters of the metabolic syndrome. With both treatments, changes in waist circumferences correlated with changes in cholesterol, LDL and HDL. Parameters of safety were not different. Conclusion: T administration has a beneficial effect on sexual dysfunction and on features of the metabolic syndrome in elderly men. The higher plasma levels of T generated with TU than with T gel (50 mg/day) were clearly more effective indicating that there is a plasma level of T / effect relationship.


Key words: Androgen • Andropause • Erectile Dysfunction • Prostate • metabolic syndrome • sex hormone binding globulin






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2007 by The American Society of Andrology.