Journal of Andrology Testis Workshop 2009
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Published-Ahead-of-Print September 6, 2006, DOI:10.2164/jandrol.106.000695

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EFFECT OF TESTOSTERONE ON INTRACAVERNOUS PRESSURE ELICITED WITH ELECTRICAL STIMULATION OF THE MEDIAL PREOPTIC AREA AND CAVERNOUS NERVE IN MALE RATS

Noriyoshi Suzuki , Yoshikazu Sato , Shin-ichi Hisasue *, Ryuichi Kato , Kazuhiro Suzuki , and Taiji Tsukamoto

* To whom correspondence should be addressed. E-mail: hisasue{at}sapmed.ac.jp.

ABSTRACT Objectives: We studied effects of castration and testosterone replacement on intracavernous pressure (ICP) elicited with electrical stimulation of the medial preoptic area (MPOA) and cavernous nerve (CN) in male rats. Findings: We measured the ICP during electrical stimulation of the MPOA and CN in castrated male rats with and without testosterone replacement. The experimental group consisted of 20-week-old male rats at 2 weeks (n=8), 4 weeks (n=8) and 8 weeks (n=8) following castration, and at 8 weeks following castration with T-replacement (n=4). Intact rats 20 weeks old (n=8) served as controls. The erectile response was expressed as ICP/blood pressure (BP) ratio. The ICP/BP ratios during the CN stimulation of the animals at 2, 4 and 8 weeks after castration were significantly lower than those of intact animals. However, these erectile responses were not eliminated. In contrast to these peripherally evoked responses, erectile responses elicited by electrical stimulation of the MPOA were eliminated following castration. After testosterone replacement, both erectile responses were restored. Conclusions: Testosterone has important roles in both the central and peripheral neural pathways for the maintenance and restoration of erectile capacity. The central control of erection shows more extensive changes following testosterone replacement than peripheral control.


Key words: Androgen • Erectile Dysfunction • MPOA • cavernous nerve




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