| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
As many as 15% of couples are unable to conceive, and males are known to be responsible for half of the instances of infertility. Although advances in medical technology have allowed some infertile couples to have children, the causes of infertility are, in most cases, unknown. Many genes are expressed exclusively in the testes, particularly in the testicular germ cells. It is reasonable to propose that functional deficiencies in the genes expressed exclusively in spermatogenesis should lead to male infertility when there is no observable abnormality in the somatic cells of various organs. Hence, in order to understand idiopathic male infertility, comprehensive isolation of the genes expressed specifically in the testes, and characterization of the gene products in spermatogenesis, are essential. Here, we describe the cloning and characterization of germ cell-specific genes and analyses of infertility resulting from mutations of human germ cell-specific genes in our laboratory.
This article has been cited by other articles:
 |
|
 |
|
  M. Rajkovic, K. A. H. Iwen, P. J. Hofmann, A. Harneit, and J. M. Weitzel Functional cooperation between CREM and GCNF directs gene expression in haploid male germ cells Nucleic Acids Res., April 1, 2010; 38(7): 2268 - 2278. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Imai, N. Hakkaku, R. Iwamoto, J. Suzuki, T. Suzuki, Y. Tajima, K. Konishi, S. Minami, S. Ichinose, K. Ishizaka, et al. Depletion of Selenoprotein GPx4 in Spermatocytes Causes Male Infertility in Mice J. Biol. Chem., November 20, 2009; 284(47): 32522 - 32532. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Takabayashi, Y. Yamauchi, M. Tsume, M. Noguchi, and H. Katoh A Spontaneous Smc1b Mutation Causes Cohesin Protein Dysfunction and Sterility in Mice Exp Biol Med, August 1, 2009; 234(8): 994 - 1001. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Wang, M. Chinnam, J. Wang, Y. Wang, X. Zhang, E. Marcon, P. Moens, and D. W. Goodrich Thoc1 Deficiency Compromises Gene Expression Necessary for Normal Testis Development in the Mouse Mol. Cell. Biol., May 15, 2009; 29(10): 2794 - 2803. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhou, D. Qin, A. Tang, D. Zhou, J. Qin, B. Yan, R. Diao, Z. Jiang, Z. Cai, and Y. Gui Developmental expression pattern of a novel gene, TSG23/Tsg23, suggests a role in spermatogenesis Mol. Hum. Reprod., April 1, 2009; 15(4): 223 - 230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tokuhiro, M. Hirose, Y. Miyagawa, A. Tsujimura, S. Irie, A. Isotani, M. Okabe, Y. Toyama, C. Ito, K. Toshimori, et al. Meichroacidin Containing the Membrane Occupation and Recognition Nexus Motif Is Essential for Spermatozoa Morphogenesis J. Biol. Chem., July 4, 2008; 283(27): 19039 - 19048. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yamakawa, K. Yoshida, H. Nishikawa, T. Kato, and T. Iwamoto Comparative Analysis of Interindividual Variations in the Seminal Plasma Proteome of Fertile Men With Identification of Potential Markers for Azoospermia in Infertile Patients J Androl, November 1, 2007; 28(6): 858 - 865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Tokuhiro, Y. Miyagawa, S. Yamada, M. Hirose, H. Ohta, Y. Nishimune, and H. Tanaka The 193-Base Pair Gsg2 (Haspin) Promoter Region Regulates Germ Cell-Specific Expression Bidirectionally and Synchronously Biol Reprod, March 1, 2007; 76(3): 407 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. He, W.-Y. Chan, and M. Dym Microarray technology offers a novel tool for the diagnosis and identification of therapeutic targets for male infertility Reproduction, July 1, 2006; 132(1): 11 - 19. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
