Journal of Andrology Testis Workshop 2009
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published-Ahead-of-Print November 22, 2005, DOI:10.2164/jandrol.05122

This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
jandrol.05122v2    most recent
Author Manuscript (PDF)
Author Manuscript (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hetic, S.
Right arrow Articles by Cooper, T. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hetic, S.
Right arrow Articles by Cooper, T. G.

Relationship of cytoplasmic droplets to motility, migration in mucus and volume regulation of human spermatozoa

Sabina Hetic , Ching-Hei Yeung , Barbara Sonntag , Eberhard Nieschlag , and Trevor G. Cooper *

* To whom correspondence should be addressed. E-mail: cooper{at}uni-muenster.de.

A significantly greater percentage of motile than immotile spermatozoa bore droplets at the osmolality of semen and cervical mucus. The percentage of spermatozoa with droplets was not significantly correlated to the osmolality of semen or their extent of cell swelling in response to quinine in hypotonic medium. Droplets appeared slightly more frequently (i.e. were more obvious) in the presence of quinine, which blocks regulatory volume decrease, suggesting that they are the major site of volume expansion. There was no selection for or against droplet-bearing spermatozoa migrating through viscous surrogate mucus at high or low osmolality. Sperm swelling in response to quinine at mucus osmolality was significantly greater in fathers than patients whose partners had no fertility problem. Therefore cytoplasmic droplets are not deleterious to sperm motility and may be related to physiological volume regulation which may be predictive of some forms of human male infertility.




This article has been cited by other articles:


Home page
 Biol. Reprod.Home page
C.-H. Yeung, C. Callies, A. Rojek, S. Nielsen, and T. G. Cooper
Aquaporin Isoforms Involved in Physiological Volume Regulation of Murine Spermatozoa
Biol Reprod, February 1, 2009; 80(2): 350 - 357.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2005 by The American Society of Andrology.