Journal of Andrology
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Published-Ahead-of-Print October 29, 2009, DOI:10.2164/jandrol.109.008235
Journal of Andrology, Vol. 31, No. 1, January/February 2010
Copyright © American Society of Andrology
DOI: 10.2164/jandrol.109.008235

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Part 1 - Regulation of Testis Development

Illuminating Testis Morphogenesis in the Mouse

LIESL NEL-THEMAAT*, GABRIEL GONZALEZ*, HARUHIKO AKIYAMA{dagger} AND RICHARD R. BEHRINGER*

From the * Department of Genetics, University of Texas, M. D. Anderson Cancer Center, Houston, Texas; and the {dagger} Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Correspondence to: Dr Richard Behringer, Department of Genetics, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 (e-mail: rrb{at}mdanderson.org).



Abstract

The mammalian testis is a complex organ composed of multiple cell types that are organized into seminiferous tubules and an interstitium, producing spermatozoa and hormones, respectively. During embryogenesis, the testis forms from the genital ridge associated with the embryonic kidney called the mesonephros. After germ cells migrate into the genital ridge, the Sertoli cell–germ cell mass forms and undergoes morphogenetic changes to generate testis cords, the precursors of the seminiferous tubules. Static images of the fetal testis at sequential stages of development provide structural information about cord formation. Transgenic mice that express fluorescent protein reporters offer new opportunities for time-lapse imaging to visualize live cells and their behaviors during testis differentiation and morphogenesis.

     Key words: Fetal gonad, seminiferous tubule, fluorescent protein, time-lapse imaging




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