Journal of Andrology
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Published-Ahead-of-Print July 31, 2008, DOI:10.2164/jandrol.107.004309
Journal of Andrology, Vol. 29, No. 6, November/December 2008
Copyright © American Society of Andrology
DOI: 10.2164/jandrol.107.004309

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Genetic Screening in Infertile Mexican Men: Chromosomal Abnormalities, Y Chromosome Deletions, and Androgen Receptor CAG Repeat Length

SANDRA GUADALUPE MARTÍNEZ-GARZA*, MAYRA CELINA GALLEGOS-RIVAS*, MARCOS VARGAS-MACIEL*, JUAN MANUEL RUBIO-RUBIO*, MARIO ESPINOSA DE LOS MONTEROS-RODRÍGUEZ*, CLAUDIA GONZÁLEZ-ORTEGA*, PATRICIA CANCINO-VILLARREAL*, LUIS G. VAZQUEZ DE LARA{dagger} AND ANTONIO MARTÍN GUTIÉRREZ-GUTIÉRREZ*

From the * Instituto de Ciencias en Reproducción Humana Vida (Instituto Vida), León, Guanajuato, México; and the {dagger} Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, México.

Correspondence to: Sandra Guadalupe Martínez-Garza, Instituto de Ciencias en Reproducción Humana Vida (Instituto Vida), Plaza Las Américas 115, Col Jardines del Moral, León, Guanajuato, México, CP 37160 (e-mail: samartin30{at}yahoo.com).


In our study, we analyzed chromosomal abnormalities, Y chromosome deletions, androgen receptor CAG repeat length and their association with defective spermatogenesis in infertile Mexican men. Eighty-two infertile patients and 40 controls were screened for karyotypic abnormalities, Y chromosome microdeletions, and CAG repeats. Nine infertile males (11%) carried chromosomal abnormalities and 10 (12.2%) presented Y chromosome microdeletions. The mean CAG repeat length was 21.6 and 20.88 base pairs in idiopathic infertile males and controls, respectively. Our results suggest that chromosomal aberrations and Y-chromosomal microdeletions are related to male infertility in Mexican men. In addition, expansion of the CAG repeat segments of the androgen receptor is not correlated with male idiopathic infertility.

     Key words: Oligospermia, karyotype, microdeletion, trinucleotide repeat




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