Figure 5. Plots of tubule differentiation indices (TDI) for groups of irradiated rats
receiving different hormone treatments against the levels of hormones
previously shown to affect the TDI (Shetty
et al, 2006). The TDI for groups of rats not treated with
flutamide vs (A) intratesticular testosterone concentrations (ITT) or (B) a
linear combination of ITT (ng/g testis) plus 3 times the serum
follicle-stimulating hormone (FSH, ng/mL; ITT + 3x FSH). The TDI for
groups of irradiated rats treated with flutamide vs (C) ITT + 3x FSH or
(D) FSH concentration. Data points correspond to groups of irradiated rats
receiving the following different hormone treatments: A indicates injections
of the gonadotropin-releasing hormone (GnRH) antagonist acyline; T,
implantation with Silastic capsules containing testosterone with the length
(cm) indicated; E, implantation with 0.5-cm Silastic capsules containing
estradiol-17β; F, implantation with 20-cm total length Silastic capsules
containing flutamide. (
) no hormone treatment; (
) A; (
) A+6T;
(
) A+24T; (•) E; (
) A+E; (
) A+6T+E; (
) A+24T+E;
(
) A+F; (
)
A+F+6T; (
) A+F+E;
(
) A+F+6T+E;
(
) A+F+12T+E; (#) A+F+24T+E. Data points for groups treated with
estradiol-17β (filled symbols) and groups not treated with estrogen (open
symbols) were fitted separately with sigmoidal 3-parameter regression curves,
(n = 4–24).
