|
Agent
|
Mode of Action
|
Animal Data
|
Human Data
|
| Systemic |
Tacrolimus (FK506) |
Immunosuppressant immunophilin ligand |
++ |
NTD |
| |
GPI compounds |
Nonimmunosuppressant immunophilin ligand |
+ |
NTD |
| |
FK1706 |
Nonimmunosuppressant immunophilin ligand |
+ |
NTD |
| |
Erythropoietin |
? |
+ |
– |
| |
PDE5i |
? |
+ |
+ |
| Local |
Neurotrophic factors |
Varied |
+ |
NTD |
|
Neurostimulatory electrodes
|
?
|
+
|
NTD
|
|
| Abbreviations: NTD, none to date; PDE5i, phosphodiesterase type 5 inhibitors;
–, negative study; +, small amount of positive data; ++, large amount of
positive data. |
|
