| Phthalate Metabolitec |
FSHd,e |
LHd,e |
Inhibin Bf |
Testosteronef |
T:LH ratiod,e |
SHBGd,e |
FAId,e |
Estradiolf |
T:E2 ratiod,e |
Prolactind,e |
|
| MEP |
0.98 (0.91, 1.06) |
0.98 (0.91, 1.04) |
0.73 (-9.99, 11.4) |
8.87 (-7.18, 24.9) |
1.03 (0.95, 1.11) |
0.97 (0.91, 1.02) |
1.04 (0.99, 1.09) |
0.71 (-0.97, 2.40) |
1.00 (0.92, 1.07) |
0.97 (0.91, 1.03) |
| MBP |
1.02 (0.97, 1.08) |
1.01 (0.97, 1.06) |
1.34 (-5.98, 8.66) |
-4.65 (-15.7, 6.33) |
0.99 (0.94, 1.04) |
1.02 (0.98, 1.06) |
0.98 (0.94, 1.01) |
-0.47 (-1.62, 0.68) |
1.01 (0.96, 1.07) |
1.00 (0.96, 1.04) |
| MBzP |
0.98 (0.92, 1.04) |
1.00 (0.95, 1.05) |
1.81 (-6.54, 10.2) |
4.58 (-7.91, 17.0) |
1.02 (0.97, 1.09) |
1.00 (0.95, 1.04) |
1.03 (0.99, 1.07) |
-0.21 (-1.53, 1.09) |
1.04 (0.98, 1.11) |
1.01 (0.96, 1.06) |
| MEHP |
1.03 (0.97, 1.10) |
0.97 (0.92, 1.02) |
-1.32 (-9.82, 7.18) |
-14.9 (-27.5, -2.30)g |
0.99 (0.93, 1.05) |
0.99 (0.94, 1.03) |
0.98 (0.96, 1.00)h |
-2.04 (-3.37, -0.73)g |
1.06 (1.00, 1.12)h |
1.00 (0.95, 1.05) |
| MEHHPb |
0.97 (0.89, 1.05) |
0.98 (0.91, 1.06) |
-2.45 (-15.9, 11.0) |
-9.33 (-25.3, 6.60) |
1.01 (0.93, 1.08) |
1.04 (0.98, 1.11) |
0.95 (0.90, 1.00)g |
-1.32 (-2.98, 0.33) |
1.03 (0.95, 1.13) |
1.01 (0.94, 1.08) |
| MEOHPb |
0.96 (0.90, 1.04) |
0.99 (0.93, 1.06) |
-1.22 (-13.4, 10.9) |
-8.88 (-23.4, 5.59) |
1.00 (0.94, 1.07) |
1.05 (0.99, 1.11)h |
0.95 (0.91, 0.99)g |
-1.09 (-2.60, 0.42) |
1.02 (0.95, 1.11) |
1.01 (0.95, 1.08) |
| Sum DEHPb |
0.98 (0.92, 1.04) |
0.99 (0.94, 1.04) |
-1.53 (-11.2, 8.07) |
-6.35 (-17.8, 5.10) |
1.00 (0.95, 1.06) |
1.03 (0.99, 1.08) |
0.96 (0.93, 1.00)g |
-1.03 (-1.15, 0.16)h |
1.03 (0.97, 1.10) |
1.03 (0.97, 1.10) |
| MEHP%b |
1.01 (0.92, 1.11) |
0.98 (0.90, 1.06) |
6.88 (-7.78, 21.5) |
7.13 (-10.3, 24.6) |
1.00 (0.99, 1.01) |
0.96 (0.90, 1.02) |
1.05 (0.99, 1.11)h |
-2.01 (-3.81, -0.21)g |
1.14 (1.04, 1.25)g |
0.95 (0.88, 1.03) |
|
| Abbreviations: BMI, body mass index; DEHP, di(2-ethylhexyl) phthalate; FAI,
free androgen index; FSH, follicle-stimulating hormone; LH, luteinizing
hormone; MBP, monobutyl phthalate; MBzP, monobenzyl phthalate; MEHHP,
mono(2-ethyl-5-hydroxyhexyl) phthalate; MEHP, mono(2-ethylhexyl) phthalate;
MEHP%, proportion of DEHP metabolites in the urine measured as MEHP; MEOHP,
mono(2-ethyl-5-oxohexyl) phthalate; MEP, monoethyl phthalate; SG, specific
gravity; SHBG, sex hormone—binding globulin; T:E2 ratio,
ratio of testosterone to estradiol; T:LH ratio, ratio of testosterone to
luteinizing hormone. |
| aAdjusted for age, BMI, current smoking, season, and time of day blood sample
was collected. Testosterone and estradiol were additionally adjusted for SHBG. |
| bn = 221 for MEHHP, MEOHP, sum of DEHP metabolites, and MEHP%. |
| cIn all models In transformations of urinary phthalate metabolite
concentrations were used. |
| dFor FSH, LH, SHBG, FAI, T:LH, T:E2, and prolactin, In
transformations of were used. Inhibin B, testosterone, and estradiol were
modeled untransformed. |
| eCoefficient represents a multiplicative change in hormone level for an IQR
change in phthalate metabolite concentration after back transformation of both
hormone and phthalate metabolite concentrations. For an IQR change in
phthalate metabolite concentration, a coefficient equal to 1.0 indicates no
change in hormone level, a coefficient <1.0 indicates a multiplicative
decrease in hormone level, and a coefficient >1.0 indicates a
multiplicative increase in hormone level. |
| fCoefficient represents the change in hormone level for an IQR change in
phthalate metabolite concentration after back transformation of the phthalate
metabolite concentrations. For an IQR change in phthalate metabolite
concentration, a coefficient equal to 0 indicates no change in hormone level,
a coefficient <0 indicates a decrease in hormone level, and a coefficient
>0 indicates an increase in hormone level. |
gP  .05. |
| hP < .1. |
|
