| Study |
n |
ART |
Assay |
PL, % |
Abn Test, % |
Sens |
Spec |
PPV |
NPV |
OR (95% CI) |
|
| Check et al, 2005 |
104 |
ICSI |
SCSA |
47 |
24 |
0.31 |
0.83 |
0.63 |
0.58 |
2.27 (0.45-11.59) |
| Zini et al, 2005b |
60 |
ICSI |
SCSA |
16 |
19 |
0.40 |
0.85 |
0.33 |
0.88 |
3.67 (0.46-29.42) |
| Borini et al, 2006 |
82 |
IVF |
TUNEL |
6 |
11 |
0.91 |
0.94 |
0.50 |
0.99 |
160 (0.18-144708) |
| Borini et al, 2006 |
50 |
ICSI |
TUNEL |
25 |
25 |
0.97 |
0.99 |
0.97 |
0.99 |
2700 (0.38-2 x 107) |
| Benchaib et al, 2007 |
84 |
IVF |
TUNEL |
15 |
15 |
0.50 |
0.91 |
0.50 |
0.91 |
10.0 (0.87-114.8) |
| Benchaib et al, 2007 |
218 |
ICSI |
TUNEL |
12 |
15 |
0.38 |
0.88 |
0.30 |
0.91 |
4.54 (0.89-23.28) |
| Bungum et al, 2007 |
388 |
IVF |
SCSA |
24 |
14 |
0.11 |
0.85 |
0.19 |
0.76 |
0.73 (0.23-2.33) |
| Bungum et al, 2007 |
223 |
ICSI |
SCSA |
19 |
40 |
0.50 |
0.63 |
0.24 |
0.84 |
1.69 (0.63-4.49) |
| Frydman et al, 2008 |
117 |
IVF |
TUNEL |
19 |
32 |
0.64 |
0.75 |
0.37 |
0.90 |
5.25 (1.31-21.11) |
| Lin et al, 2008 |
137 |
IVF |
SCSA |
10 |
17 |
0.29 |
0.84 |
0.17 |
0.92 |
2.16 (0.37-12.72) |
| Lin et al, 2008 |
86 |
ICSI |
SCSA |
18 |
23 |
0.50 |
0.83 |
0.40 |
0.88 |
5.00 (0.97-25.77) |
|
| Abbreviations: Abn Test, proportion of abnormal sperm DNA test amongst
documented pregnancies; ART, assisted reproductive technology; CI, confidence
interval; ICSI, intracytoplasmic sperm injection; IVF, in vitro fertilization;
NPV, negative predictive value; OR, odds ratio; PL, pregnancy loss; PPV,
positive predictive value; SCSA, sperm chromatin structure assay; Sens,
sensitivity; Spec, specificity; TUNEL, terminal deoxynucleotidyl
transferase-mediated dUTP nick end-labeling. |
|
