Journal of Andrology Proceedings of the Fifth International Conference on the Epididymis
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Table 8. Summary of genes identified
  Gene Symbol   Full Gene Name   Gene Ontology Function   Cellular Localizationa
  CYP17A1   Cytochrome P450c17-alpha-hydroxylase/17,20-lyase   C21-steroid hormone biosynthesis   Leydig cells
  CYP11A1   Cytochrome P450c11 side-chain cleavage   C21-steroid hormone biosynthesis   Leydig cells
  HSD17B6   Hydroxysteroid (17-beta) dehydrogenase 6 homolog   Androgen biosynthesis   Leydig cells
  STAR   Steroidogenic acute regulatory protein   Steroid biosynthesis   Leydig and Sertoli cells
  DHCR24   24-Dehydrocholesterol reductase   Cholesterol biosynthesis, MAP kinase phosphatise activity   Spermatogonia, Sertoli and Leydig cells
  DPEP3   Dipeptidase 3   Membrane dipeptidase activity   Spermatocytes, Leydig cells
  GSTA2   Glutathione S-transferase A2   Glutathione transferase activity   Spermatogonia
  PRPS2   Phosphoribosyl pyrophosphate synthetase 2   Kinase activity; nucleoside, nucleotide, and nucleic acid biosynthesis; and metabolism   Sertoli cells, spermatogonia, Leydig cells
  PAPSS   3'-Phosphoadenosine 5'-phosphosulfate synthase   Adenylylsulfate kinase activity; ATP binding; nucleobase, nucleoside, nucleotide, and nucleic acid metabolism; nucleotidyltransferase activity   Germ cells, Leydig cells
  HMGCS2   3-Hydroxy-3-methylglutaryl-coenzyme A synthase 2 (mitochondrial)   Cholesterol biosynthesis   Spermatogonia
  CT45-1, 3   Cancer/testis antigen CT45-1/3   Unknown   Testis
  INSL3   Insulinlike 3 (Leydig cell)   Cell-cell signaling, hormone activity, insulin receptor binding, spermatogenesis   Leydig cells
  SC4MOL   Sterol-C4-methyl oxidaselike   Steroid metabolism, sterol biosynthesis, C-4 methylsterol oxidase activity   Sertoli cells, spermatogonia
  CYB5   Cytochrome b5   Cytochrome c oxidase activity, fatty acid metabolism, transport   Spermatogonia, Leydig cells
  APOE   Apolipoprotein E   Cholesterol homeostasis, induction of apoptosis, lipid transport, lipoprotein metabolism, antioxidant activity   Sertoli cells, spermatogonia
  TAF4B   TAF4b RNA polymerase II, TATA box binding protein (TBP)—associated factor, 105 kd   Transcription factor activity   Spermatogonia, Sertoli and Leydig cells
  SYCP1   Synaptonemal complex protein 1   Synaptonemal complex formation, DNA binding, meiotic recombination, spermatogenesis   Spermatogonia, spermatocytes
  SYCP3   Synaptonemal complex protein 3   Synaptonemal complex formation, DNA binding, meiotic recombination, spermatogenesis   Spermatocytes
  DMC1   DMC1 dosage suppressor of mck1 homolog   ATP binding, damaged DNA binding, DNA repair, meiotic recombination, spermatogenesis   Germ cells, Leydig cells
  DAZL   Deleted in azoospermialike   Cell differentiation, nucleotide binding, regulation of translation, RNA binding, spermatogenesis   Spermatogonia, spermatocytes
  MSH5   mutS Homolog 5    
  TEX11   Testis expressed 11   Protein binding   Spermatogonia, Leydig cells
  TEX14   Testis expressed 14   Nucleotide binding, protein amino acid phosphorylation, protein kinase activity, transferase activity   Germ cells, Leydig cells
  TEX101   Testis expressed 101   Receptor activity   Spermatocytes, Leydig cells
  HORMAD1   HORMA domain containing 1   DNA-binding HORMA   Spermatocytes, Leydig cells
  HORMAD2   HORMA domain containing 2   DNA-binding HORMA   Germ cells, Leydig cells
  CHGA   Chromogranin A   Calcium ion binding   Germ cells
  PROK1   Prokineticin 1, (EG-VEGF)   Growth factor activity   Germ cells
  PGRMC1   Progesterone receptor membrane component 1   Receptor activity, steroid binding   Spermatogonia, Leydig cells
  RHOB   ras Homolog gene family, member B   Cell adhesion, cell differentiation, nucleotide binding, protein binding, protein transport, transformed cell apoptosis   Spermatogonia, Sertoli and Leydig cells
  WISP2   WNT1-inducible signaling pathway protein 2   Cell adhesion, cell-cell signaling, insulinlike growth factor binding, protein binding, regulation of cell growth, signal transduction   Leydig cells
  CST9L   Cystatin 9-like (mouse)   Cysteine protease inhibitor activity   Germ cells
  FLJ35767   FLJ35767 protein (similar to mouse Tex19)   Unknown  
  aCellular localization based on published data on human and/or mouse homologs as indicated in the text or in searches of the GermOnline database of the transcriptome of male gametogenesis (Chalmel et al, 2007), available at http://www.germonline.org/index.html.





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