| Domain |
Baseline |
Treatment Day 28 |
|
| Sex drive (0-8)b |
|
|
| 400 mg twice daily |
5.5 ± 0.7 |
5.2 ± 0.9 |
| 800 mg once daily |
5.0 ± 0.8 |
5.5 ± 0.9 |
| Erectile function (0-12)c |
|
|
| 400 mg twice daily |
10.6 ± 0.7 |
9.9 ± 0.7 |
| 800 mg once daily |
10.6 ± 0.7 |
9.9 ± 0.6 |
| Ejaculatory function (0-8)d |
|
|
| 400 mg twice daily |
7.7 ± 0.4 |
7.4 ± 0.5 |
| 800 mg once daily |
7.1 ± 0.4 |
7.5 ± 0.8 |
| Freedom from problems with sexual activity (0-12)e |
|
|
| 400 mg twice daily |
11.0 ± 0.6 |
10.5 ± 0.5 |
| 800 mg once daily |
10.5 ± 0.4 |
10.6 ± 0.5 |
| Overall satisfaction with sexual activity (0-4)f |
|
|
| 400 mg twice daily |
3.2 ± 0.6 |
2.9 ± 0.7 |
| 800 mg once daily |
2.4 ± 1.1 |
3.1 ± 0.8g |
|
| a Values are mean ± SD (n = 10 per group). Higher values represent
greater levels of satisfaction. |
| b Sum of two 4-point Likert scale responses to questions regarding frequency
and level of sexual drive. |
| c Sum of three 4-point Likert scale responses to questions regarding frequency
of erections, firmness of erections and ease of sexual activity with
erections. |
| d Sum of two 4-point Likert scale responses to questions regarding ease or
ejaculation and volume of ejaculate. |
| e Sum of three 4-point Likert scale responses to questions regarding lack of
problems associated with sex drive, erectile and ejaculatory function. |
| f A single 4-point Likert scale response to question regarding overall level
of satisfaction with sex life in the preceding 30 days. |
| g P < .05 compared with baseline. |
