Journal of Andrology Proceedings of the Fifth International Conference on the Epididymis
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Table 3. Dihydrotestosterone pharmacokinetics after the administration of oral testosterone in oil (CpT) or nanomilled oral testosterone (NmT) to healthy men pretreated with the GnRH agonist Lupron and dutasteridea
      Dihydrotestosterone
      Capmul
  Nanomilled
  Dose, mg   State   AUC(0-24h), ng/h/dL   Cmax, ng/dL   AUC(0-24h), ng/h/dL   Cmax, ng/dL
  200   Fasted   118 (93.4)   13 (55.8)   110 (103.8)   11 (59.3)
  400   Fasted   117b (97.4)   17b (69.2)   212c (75.3)   16c (53.4)
  400   Fed   184 (67.9)   16 (44.8)   193 (60.9)   15 (48.2)
  Abbreviations: Cmax indicates maximum concentration after dosing; AUC, area under the curve.
  aAll data are geometric means, with coefficients of variation in parentheses.
  bP < .05 vs 200 mg CpT.
  cP < .05 vs 200 mg NmT.





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