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The number of pups obtained from 10 mating pairs with defined genotypes

Male	Female	# of Pups in 16 Weeks	# of Litters	Average # of Pups per Litter

+/+	+/+	130^*	17	7.64
+/+	+/–	139^*	17	8.17
+/+	–/–	152^*	21	7.23
+/–	+/+	131 ${dagger}$	17	7.70
+/–	+/–	130 ${dagger}$	21	6.19
+/–	–/–	121 ${dagger}$	17	7.11
–/–	+/+	141 ${ddagger}$	18	7.83
–/–	+/–	63 ${ddagger}$ $§$	10	6.30
–/–	–/–	11 ${ddagger}$ \|\|	3	3.66

Totals are ^*421, ${dagger}$ 382, and ${ddagger}$ 215.
Statistical differences compared with the number of pups born in 16 weeks from wild-type x wild-type crosses (+/+ x +/+): $§$ P = .02; \|\|P = .0002.