Figure 8. The effects of paternal cyclophosphamide, doxorubicin, vincristine, and prednisone treatment on progeny outcome. At the end of the treatment, each male was mated with 2 females in pro-estrus. On day 20 of gestation females were euthanized, and the (A) preimplantation losses, (B) postimplantation losses, and (C) litter sizes were determined. Bars represent the means ± SEM (n: control, 12; 1/3x, 14; 2/3x, 9; 1x, 9 pregnant females). *P < .05 compared with controls.