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Table 2. Serum biochemicals in the experimental groups*

	Standard Chow Rats		High-Fat—Fed Obese Rats
	Vehicle	Metformin	Vehicle	Metformin

Glucose (mM)	9.3 ± 0.37	8.2 ± 0.54	8.8 ± 0.41	8.3 ± 0.42
Total cholesterol (mg/dL)	99 ± 4.6	110 ± 6.5	142 ± 10.4 ${dagger}$	126 ± 5.3
LDL ${ddagger}$ cholesterol (mg/dL)	20 ± 1.4	23 ± 2.0	36 ± 3 ${dagger}$	33 ± 2.2
HDL ${ddagger}$ cholesterol (mg/dL)	68 ± 4.6	60 ± 2.6	63 ± 8.9	51 ± 3.2
Triglycerides (mg/dL)	44 ± 6.8	51 ± 7.3	46 ± 7.6	66 ± 4.1
Insulin (ng/mL)	2.8 ± 0.26	2.5 ± 0.28	4.3 ± 0.46 ${dagger}$	2.5 ± 0.40 $§$

*Data are presented as mean ± SE for 8 rats per experimental group.
${dagger}$ P < .05 vs vehicle-treated standard chow rats.
${ddagger}$ HDL indicates high-density lipoprotein; LDL, low-density lipoprotein.
$§$ P < .05 vs vehicle treated high-fat—fed obese rats.