Journal of Andrology
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Published-Ahead-of-Print April 13, 2006, DOI:10.2164/jandrol.06008
Journal of Andrology, Vol. 27, No. 4, July/August 2006
Copyright © American Society of Andrology
DOI: 10.2164/jandrol.06008

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Journal of Andrology, Vol. 27, No. 4, July/August 2006
Copyright © American Society of Andrology


Perspectives and Editorials

Letter to the Editor

Is TESA Passé?

Jacob Rajfer, MD


To the Editor:

As a urologist who has practiced male infertility in Los Angeles for the past 26 years, I read with interest the two articles that dealt with testicular sperm aspiration via TESE and TESA in the Jan/Feb 2006 issue of Journal of Andrology and feel that a comment about these two manuscripts is warranted. First of all, both articles were, in my humble opinion, well designed to answer a number of nagging questions about sperm aspiration techniques, and the authors of both are to be congratulated for putting down on paper their vast experience on this important topic. However, in reading these two manuscripts, I got the feeling that there was at least one hidden, what I would even call subliminal, message between the lines of these two studies that I think needs to be addressed, at least by a urologist. The subliminal message that I am referring to is that TESE is considered by the cognoscenti of male infertility to be a more involved procedure than TESA, since TESE 1) entails more preparation, ie, an operating suite is required, and 2) is more invasive and painful, hence it needs to be done under general anesthesia.

I respectfully submit that this is inaccurate. TESE is, from a surgical point of view, little more than a testis biopsy, and in my ~ 26 years at our institution doing this in dozens of patients, save for one or two who requested general anesthesia because of perceived testisphobia (sic), I don't recall ever doing a TESE, regardless of whether it was multifocal (sometimes up to 6+ biopsies per testis) or unifocal, under general anesthesia and in an operating suite. In fact, at UCLA it would cost almost as much as many IVF centers charge for ICSI/IVF if I were to do a testis biopsy in the operating suite–and this does not include the surgical fee for the TESE. Cost is therefore one of a number of reasons why TESE is done under local anesthesia in the office setting. With TESE, complete anesthesia of the area, whether unilateral or bilateral, can be obtained by an intradermally injected anesthetic plus a cord block. While a few of our patients undergoing TESE have had a vasovagal reflex which simply responded to intranasal ammonia, we have never lost a testis nor had a complication of the cord block that necessitated any corrective therapy.

I for one have always assumed that those physicians who did TESA did so because they were primarily andrologists and were, therefore, not surgically trained. While this may be true or not, based on the powerful data of these two excellent studies, it seems prudent that those who perform TESA in preference to TESE need to rethink their reasons for ever considering TESA as a method of sperm aspiration, particularly in nonobstructive azoospermia.

Respectfully yours, Jacob Rajfer, MD


Footnotes

DOI: 10.2164/jandrol.06008


References

Hauser R, Yogev L, Paz G, Yavetz H, Azem F, Lessing JB, Botchan A. Comparison of efficacy of two techniques for testicular sperm retrieval in nonobstructive azoospermia: multifocal testicular sperm extraction versus multifocal testicular sperm aspiration. J Androl. 2006; 27: 28 –33.[Abstract/Free Full Text]

Kovacic B, Vlaisavljevic V, Reljic M. Clinical use of pentoxifylline for activation of immotile testicular sperm before ICSI in patients with azoospermia. J Androl. 2006; 27: 45 –52.[Abstract/Free Full Text]





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