Suggested algorithm for evaluation and management of infertile patients with increased oxidative stress in their seminal plasma. Oxidative stress should be assessed as a part of the male infertility evaluation. ROS-TAC score was calculated by applying principal component analysis to normalized values of ROS and TAC in semen specimens from a population of proven fertile donors; scores below 30 indicate the presence of oxidative stress. TAC indicates total antioxidant capacity; ROS, reactive oxygen species; COMET, single-cell microgel electrophoresis; TUNEL, terminal deoxynuceotidyl transferase-mediated deoxyuridine triphosphate-nick end labeling; SCSA, sperm chromatin structure assay; and ART, assisted reproductive technology.