Return to article

Table 1. Classification of ER ligands based on the interaction with androgen in cotransfection assays

		Modulation of Androgen Actions^*
Categories	ER Ligands	Via ER ${alpha}$	Via ERß	Via ER ${alpha}$ /ERß

I	17ß-Estradiol, Diethylestradiol	${downarrow}$	—	${downarrow}$
II	17 ${alpha}$ -Estradiol	${downarrow}$	${downarrow}$	${downarrow}$
III	ICI	${downarrow}$	—/ ${uparrow}$ ${dagger}$	${downarrow}$ /—
IV	Tamoxifen	—	${uparrow}$	${uparrow}$

* ${downarrow}$ indicates inhibitory; ${uparrow}$ potentiation; and —, no effect
${dagger}$ Potentiation only at a high dose