| |
|
|
Recovery Period
|
|
| Sets |
Cisplatin Dose, mg/kg |
Exposure Cycles |
Cycles |
Days |
Cumulative Dose of Cisplatin, mg/kg |
|
| Set 1.0/A |
1.0 |
1 |
0.5 |
17 |
5.0 |
| Set 1.0/B |
1.0 |
2 |
1 |
34 |
10.0 |
| Set 2.5/A |
2.5 |
1 |
0.5 |
17 |
12.5 |
| Set 2.5/B |
2.5 |
1 |
1.5 |
55 |
12.5 |
| Set 2.5/C |
2.5 |
2 |
1 |
34 |
25.0 |
| Set 2.5/D |
2.5 |
2 |
2.7 |
94 |
25.0 |
| Set 2.5/E |
2.5 |
2 |
4 |
136 |
25.0 |
| Set 2.5/F |
2.5 |
2 |
4.5 |
157 |
25.0 |
| Set 2.5/G |
2.5 |
4 |
2 |
70 |
50.0 |
| Set 2.5/H |
2.5 |
4 |
4 |
142 |
50.0 |
| Set 5.0/A |
5.0 |
1 |
1.5 |
55 |
25.0 |
| Set 5.0/B |
5.0 |
2 |
1 |
34 |
50.0 |
|
| *Adult C57 mice were given either 1, 2, or 4 rounds of 1, 2.5, or 5 mg/kg
cisplatin in 0.9% saline. Total cumulative dose received by each group of mice
and the recovery period after the last injection varied between groups as
indicated. Control animals in each group received a similar volume of 0.9%
saline vehicle. Each exposure set consisted of at least 3 vehicle control and
6 cisplatin-treated animals. |
|
