Journal of Andrology Proceedings of the Fifth International Conference on the Epididymis
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Table 3. Diagnostic accuracy of GPx and GR expression and activity and GSH concentrations in fresh semen with respect to forecasting successful and unsuccessful thawing results*
  Parameters   AUCROC (95% Cl)   Significance   Threshold   Sensitivity (%)   Specificity (%)   PPV   NPV
  GPx1 mRNA   0.82 (0.62-0.94)   0.03a{dagger}   >12.1   80.0   95.2   80.0   95.2
  GPx1 activity   0.74 (0.53-0.88)   0.04a   >445   45.5   94.1   83.3   72.7
  GPx4 mRNA   0.94 (0.78-0.99)   0.02a   >7.2   80.0   100.0   100.0   95.5
  GPx4 activity   0.74 (0.54-0.89)   0.02b   >145   72.7   82.4   72.7   82.4
  GR mRNA   0.65 (0.44-0.82)   0.27b   ≤12.3   83.3   57.1   35.7   92.3
  GR activity   0.60 (0.41-0.78)   0.35b   ≤0.4   58.3   70.6   58.3   70.6
  GSH   0.73 (0.52-0.87)   0.04a   ≤2.1   81.8   70.6   64.3   85.7
  *GPx indicates glutathione peroxidase; GR, glutathione reductase; GSH, glutathione (reduced); AUCROC, area under the curve in a receiver operating characteristic analysis; PPV, positive predictive value; NPV, negative predictive value; and mRNA, messenger RNA
  {dagger}Values with different letters were significantly different (P < .01)





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