Figure 5. Percentage of epididymal spermatozoa with tail moments greater than 15. Cells were collected on days 14, 21, and 28 after (A) acute 1-day, (B) subchronic 4-day, and (C) chronic cyclophosphamide exposure and then analyzed for DNA damage measured as comet tail moment. The percentage of abnormal sperm presenting increased DNA damage is shown for saline (open bars), low-dose cyclophosphamide (crosshatched bars), and high-dose cyclophosphamide (black bars). TM indicates tail moment. * Significantly different from time-matched controls; significantly different from time-matched low-dose cyclophosphamide group (P < .05).