
Figure 3. Sequence analysis of mitochondrial genes of the
oligoasthenoteratozoospermic man showed 8 nucleotide substitutions in
cytochrome oxidase I, 13 substitutions and 2-bp deletions in cytochrome
oxidase II, 5 substitutions in adenosine triphosphate synthase 8 (ATPase8),
and 10 substitutions in ATPase6 in sperm mitochondrial DNA (mtDNA). These
substitutions created 9 missense mutations, while the rest were silent
mutations (*). A 2-bp deletion in cytochrome oxidase II (8195 and 8196)
introduced a stop codon (AGA) at 8216, which possibly resulted in a truncated
protein.