Journal of Andrology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published-Ahead-of-Print May 13, 2010, DOI:10.2164/jandrol.110.010413

This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
31/5/500    most recent
Author Manuscript (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Li, D. K.
Right arrow Articles by Yuan, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Li, D. K.
Right arrow Articles by Yuan, W.

Relationship between Urine Bisphenol-A (BPA) Level and Declining Male Sexual Function

De-Kun Li *, ZhiJun Zhou , Maohua Miao , Yonghua He , Dandan Qing , Tongjun Wu , JinTao Wang , Xiaoping Weng , Jeannette Ferber , Lisa Herrinton , Qianxi Zhu , ErSheng Gao , and Wei Yuan

* To whom correspondence should be addressed. E-mail: dkl{at}dor.kaiser.org.

The adverse effect of Bisphenol-A (BPA) on the male reproductve system observed in animal studies has not been well examined in human populations. BPA is potentially a serious public health problem due to its widespread presence in the human body. This study was conducted among 427 male workers in regions where high levels of BPA exposure existed. All participants provided urine samples which were tested for BPA concentration using high-performance liquid chromatography. Male sexual dysfunction was ascertained using standard male sexual function inventories. Male sexual dysfunction was measured in four domains using seven indices. After controlling for potential confounders using linear regression, increasing urine BPA level was associated with worsening male sexual function on a continuous scale. All seven indices demonstrated this negative dose-response correlation. Increasing urine BPA level was associated with decreased sexual desire (p< 0.001), more difficulty having an erection (p<0.001), lower ejaculation strength (p<0.001), and lower level of overall satisfaction with sex life (p<0.01). A similar negative correlation was also observed among participants exposed to BPA from only environmental sources (no occupational exposure to BPA), although the estimates in this group were less stable due to a smaller sample size. Our results reveal a dose-response correlation between a biological measure of urine BPA level and declining male sexual function. This finding may enhance the understanding of the BPA effect in human populations and have important public health implications given the widespread human exposure to BPA.


Key words: Erectile Dysfunction • BPA • Bisphenol-A • cohort study • epidemiology • sexual dysfunction




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
E. Chung, M. C. Genco, L. Megrelis, and J. V. Ruderman
Effects of bisphenol A and triclocarban on brain-specific expression of aromatase in early zebrafish embryos
PNAS, October 25, 2011; 108(43): 17732 - 17737.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
W. G. Foster and C. L. Hughes
Gene Expression in Oogenesis and Implications for Transgenerational Effects of Environmental Toxicants
Biol Reprod, January 1, 2011; 84(1): 2 - 4.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2010 by The American Society of Andrology.