Journal of Andrology
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Published-Ahead-of-Print July 29, 2010, DOI:10.2164/jandrol.110.010223

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Reduced Vasoreactivity in Corpus Cavernosum of the Akita Mouse

Lijing Jia , Donghua Xie , Xiuli Wang , Yan Liu , Yukun Li , and Xiaoyang Zhang *

* To whom correspondence should be addressed. E-mail: zhangxy722{at}gmail.com.

Objectives: Diabetes Mellitus (DM) is an important risk factor of erectile dysfunction (ED). We sought to investigate the nature and mechanism of the vasoreactivity in Akita (Ins2 (WT/C96Y)) mice, a model of genetic non-obese type 1 diabetes that recapitulates human type 1 diabetes. Materials and Methods: Eight wild-type (WT) mice (Group 1) and 8 Akita mice (Group 2) were used for this study. Corporal tissues were harvested and studied for endothelium-dependent and endothelium-independent vasoreactivities by isometric tension study; levels of VEGF and cyclic guanosine monophosphate (cGMP) were studied using enzyme immunoassay assay (ELISA). Results: Endothelium-dependent and endothelium-independent vasoreactivities, cGMP, and VEGF were significantly decreased in the corporal tissues of Akita mice. Conclusions: Corporal tissues from Akita mice demonstrate many of the major functional and biochemical changes found in humans with ED. This model could serve as a valuable tool for advancing our understanding of the role of DM plays in the pathogenesis of ED.


Key words: Erectile Dysfunction • Penis • diabetes mellitus






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