Journal of Andrology
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Published-Ahead-of-Print October 29, 2009, DOI:10.2164/jandrol.109.008367

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LDHC THE ULTIMATE TESTIS SPECIFIC GENE

Erwin Goldberg *, Edward M. Eddy , Chongwen Duan , and Fanny Odet

* To whom correspondence should be addressed. E-mail: erv{at}northwestern.edu.

Lactate dehydrogenase C (LDHC) was, to the best of our knowledge, the first testis specific isozyme discovered in male germ cells. In fact, this was accomplished shortly before "Isozymes or isoenzymes" became a field of study. LDHC was detected initially in human spermatozoa and spermatogenic cells of the testes by gel electrophoresis. Immunohistochemistry was used to localize LDHC first in early pachytene primary spermatocytes with an apparent increase in quantity following meiosis to its final localization in and on the principle piece of the sperm tail. After several decades of biological, biochemical and genetic investigations we now know that the lactate dehydrogenase isozymes are ubiquitous in vertebrates, developmentally regulated, tissue and cell specific and multi-functional. Here we will review the history of LDHC and the work that demonstrates clearly that it is required for sperm to accomplish their ultimate goal, fertilization.


Key words: Fertility • Sperm • Testis • glycolysis • lactate dehydrogenase C




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