Journal of Andrology Testis Workshop 2009
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Published-Ahead-of-Print November 19, 2009
Journal of Andrology 2009, DOI:10.2164/jandrol.109.007559

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Nonbacterial Prostatitis in Kunming Mouse Induced by Long-Term Stimuli of Passive Sexual Abstinence

Chen Lv , Zhaohui Zhong , Zhiping Wu , Ning Xiao , Minggen Yang , and Xiaokun Zhao *

* To whom correspondence should be addressed. E-mail: xiaokunzhao2002{at}yahoo.com.

In this study, a state of sexual abstinence had been imitated in Kun-Ming male mice. Further assessment on the body and prostate weight, and histomorphometric changes of the prostate showed that nonbacterial prostatitis in Kun-Ming mice could be induced by long-term stimuli of passive sexual abstinence, and the normal physiological state of the mice could be kept in the process of induction. The analysis of the result suggests that copulation might be a protective factor in the process of non-bacterial prostatitis. This mouse model may be used for additional studies to discover molecular pathways, genetic influences, environmental factors, and management strategies for nonbacterial prostatitis. The underlying mechanisms of this model may include immune response on prostate antigen, chronic pelvic congestion, and disturbance of hormone regulation and others, while requires confirmation from further research.


Key words: Prostate • Kunming Mice • Nonbacterial Prostatitis • Sexual Abstinence






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