Journal of Andrology Testis Workshop 2009
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Published-Ahead-of-Print December 3, 2009
Journal of Andrology 2009, DOI:10.2164/jandrol.109.007542

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Estrogen Receptor alpha and beta Polymorphisms Are Associated with Semen Quality

Leandros A. Lazaros , Nectaria V. Xita , Apostolos I. Kaponis , Konstantinos A. Zikopoulos , Nicolaos I. Plachouras , and Ioannis A. Georgiou *

* To whom correspondence should be addressed. E-mail: igeorgio{at}uoi.gr.

The role of estrogen receptor alpha and estrogen receptor beta gene polymorphisms on semen quality is the aim of our study. One hundred fourteen men were examined in the IVF Unit and it was found that 85 men had normal sperm count and 29 were oligozoospermic. The genotype analysis, on DNA extracted from spermatozoa, revealed that in men with oligozoospermia (sperm concentration < 20 x 106 spermatozoa/ml), those with ERalpha 397T/C and 397C/C genotypes had higher sperm motility while those with 397T/T genotype had lower sperm motility (P=0.003). In addition, men with ERalpha 351A/A genotype had lower sperm motility compared with 351A/G and 351G/G genotypes (P=0.013). Furthermore, normal sperm count men with ERalpha 397T/T genotype had higher sperm concentration compared with 397T/C and 397C/C genotypes (P=0.016), while men with ERalpha 351A/A genotype had higher sperm concentration from those with 351A/G and 351G/G genotypes (P=0.05). In contrast, no significant associations were found between ERbeta (1082G->A and 1730A->G) polymorphisms and sperm concentration or motility. In conclusion, ERalpha polymorphisms were found to be associated with sperm motility and concentration supporting the significance of this gene in spermatogenesis and semen quality.


Key words: Infertility • Semen Analysis • Sperm • Estrogen receptor






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