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Journal of Andrology, Vol 9, Issue 2 78-81, Copyright © 1988 by The American Society of Andrology

JOURNAL ARTICLE

Immunohistochemical localization of beta-endorphin in hyperplastic interstitial tissue of the human testis

G. Spera, E. Di Benedetto, P. Falaschi, A. Fabbri, G. Lauro and M. Bolotti
Department of Andrology and Cellular Biology, University of Rome, La Sapienza, Italy.

The immunohistochemical localization of beta-endorphin in the normal testis (two patients) and in the pathologic testis (two cases of Sertoli Cell Only Syndrome, two cases of Klinefelter Syndrome, two cases of post-orchitis tubular sclero-hialinosis) was investigated. No beta-endorphin immunostaining was detected in the normal testis, while positive beta-endorphin immunostaining has been observed in pathologic tissues. These results indicate that, as in animals, beta-endorphin is present in human Leydig cells and may play a local role in regulating male reproductive function.


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L. Gnessi, A. Fabbri, and G. Spera
Gonadal Peptides as Mediators of Development and Functional Control of the Testis: An Integrated System with Hormones and Local Environment
Endocr. Rev., August 1, 1997; 18(4): 541 - 609.
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Copyright © 1988 by The American Society of Andrology.