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Journal of Andrology, Vol 6, Issue 5 300-305, Copyright © 1985 by The American Society of Andrology

JOURNAL ARTICLE

Selective luminal absorption of L-carnitine from the proximal regions of the rat epididymis. Possible relationships to development of sperm motility

B. T. Hinton and H. Hernandez

The absorption of L-carnitine from the duct of the proximal regions of the rat epididymis was investigated using a stopped-flow, split-droplet microperfusion technique. L-carnitine was absorbed from the duct of the proximal caput epididymidis by a time-dependent and saturable transport system (Km = 25 micron; Vmax = 0.65 pmoles absorbed/min/mm3 tubular volume). Furthermore, absorption appeared to be primarily sodium-independent, although the existence of a minor sodium-dependent pathway cannot be ruled out. A similar transport system was not evident along the distal caput epididymidis, where absorption of L-carnitine was attributable to passive diffusion only. The inward and outward movement of L-carnitine across the epithelium of the proximal and distal caput epididymidis appears to be regulated so that the spermatozoa come into contact with high levels of L-carnitine in the distal caput region.


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I. Tamai, R. Ohashi, J.-i. Nezu, Y. Sai, D. Kobayashi, A. Oku, M. Shimane, and A. Tsuji
Molecular and Functional Characterization of Organic Cation/Carnitine Transporter Family in Mice
J. Biol. Chem., December 15, 2000; 275(51): 40064 - 40072.
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Copyright © 1985 by The American Society of Andrology.