Journal of Andrology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pekary, A. E.
Right arrow Articles by Friedman, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pekary, A. E.
Right arrow Articles by Friedman, S.

Journal of Andrology, Vol 4, Issue 6 399-407, Copyright © 1983 by The American Society of Andrology

JOURNAL ARTICLE

Human semen contains thyrotropin releasing hormone (TRH), a TRH-homologous peptide, and TRH-binding substances

A. E. Pekary, J. M. Hershman and S. Friedman

High levels of thyrotropin releasing hormone (TRH) and TRH-homologous peptide, with the general structure pGlu=X-Pro-NH2 where X is either Histidine (His) or a neutral amino acid residue, have been identified in rat and human prostate (Pekary et al, 1980, 1981a, 1982c). Because of the secretory nature of prostatic tissue, it was considered likely that these peptides would be measurable in human semen. The mean (+/- SD) TRH immunoreactivity (TRH IR) in semen from 26 normal donors, aged 26 and 41 years, was found to be 12.2 +/- 5.2 ng/ml. TRH and TRH-homologous peptide, were undetectable in unconcentrated human serum. TRH IR levels in semen from azoospermic donors were in the normal range. The level of TRH IR in semen from vasectomized donors was significantly less (P less 0.01) than in semen from normal subjects. Evidence for at least two TRH-binding substances, which coextract and bind to added synthetic TRH, was obtained by exclusion and cation exchange chromatography. Purification of extracts of human semen by TRH affinity chromatography or gradient, reversed phase high pressure liquid chromatography (HPLC) revealed two major TRH immunoreactive peptides, one corresponding to the TRH-homologous peptide previously reported in rat and human prostate and one cochromatographing with synthetic TRH.


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
A. J. Ruiz-Alcaraz and J. del Rio-Garcia
Characterization of a Circulating N-Extended Form of the Thyrotropin-Releasing Hormone-Like Peptide pGlu-Glu-Pro Amide in Human Plasma
J. Clin. Endocrinol. Metab., December 1, 2003; 88(12): 6002 - 6007.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
W. Klootwijk, E. Sleddens-Linkels, R. D. H. de Boer, C. A. Jansen, R. Autar, W. W. de Herder, E.R. Boeve, T. J. Visser, and W. J. de Greef
Renal Clearance of the Thyrotropin-Releasing Hormone-Like Peptide Pyroglutamyl-Glutamyl-Prolineamide in Humans
J. Clin. Endocrinol. Metab., September 1, 1997; 82(9): 3068 - 3073.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1983 by The American Society of Andrology.