Journal of Andrology
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Published-Ahead-of-Print April 23, 2009, DOI:10.2164/jandrol.108.007344
Journal of Andrology, Vol. 31, No. 2, March/April 2010
Copyright © American Society of Andrology
DOI: 10.2164/jandrol.108.007344

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A Novel Treatment Modality in Patients With Premature Ejaculation Resistant to Conventional Methods: The Neuromodulation of Dorsal Penile Nerves by Pulsed Radiofrequency

SEREF BASAL*, SERDAR GOKTAS*, ATILLA ERGIN{dagger}, IBRAHIM YILDIRIM*, ABDULKADIR ATIM*, LUTFI TAHMAZ* AND MURAT DAYANC*

From the * Department of Urology and the {dagger} Department of Anesthesiology, Gülhane Military Medical Academy, Ankara, Turkey.

Correspondence to: Dr Seref Basal, Department of Urology, Gülhane Military Medical Academy, School of Medicine, 06018 Ankara, Turkey (e-mail: serefbasal{at}gmail.com).


Premature ejaculation (PE) is the most common sexual problem experienced by men, and it affects 20%–30% of them. Pulsed radiofrequency (PRF) neuromodulation has been shown to be an effective treatment for a wide range of pain conditions. We used PRF to treat PE by desensitizing dorsal penile nerves in patients resistant to conventional treatments. Fifteen patients with a lifelong history of PE, defined as an intravaginal ejaculatory latency time (IELT) of <1 minute that occurred in more than 90% of acts of intercourse and was resistant to conventional treatments, were enrolled in this study. Patients with erectile dysfunction were excluded. The mean age of the patients was 39 ± 9 years. Before and 3 weeks after the treatment, IELT and sexual satisfaction score (SSS; for patients and their partners) were obtained. The mean IELTs before and 3 weeks after procedure were 18.5 ± 17.9 and 139.9 ± 55.1 seconds, respectively. Side effects did not occur. Mean SSSs of patients before and after treatment were 1.3 ± 0.3 and 4.6 ± 0.5, and mean SSSs of partners before and after treatment were 1.3 ± 0.4 and 4.4 ± 0.5, respectively. In all cases, IELT and SSS were significantly increased (P < .05). None of the patients or their wives reported any treatment failure during the follow-up period. The mean follow-up time was 8.3 ± 1.9 months. It is early to conclude that this new treatment modality might be used widely for the treatment of PE; however, because it is an innovative modality, placebo-controlled studies (eg, sham procedure), with larger numbers of patients and including assessment of penile sensitivity (eg, biothesiometry), are needed.

     Key words: Sexual dysfunction, andrology




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S. Basal, A. Ergin, I. Yildirim, S. Goktas, A. Atim, A. Sizlan, H. C. Irkilata, E. Kurt, and M. Dayanc
A Novel Treatment of Chronic Orchialgia
J Androl, January 1, 2012; 33(1): 22 - 26.
[Abstract] [Full Text] [PDF]


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