Journal of Andrology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Published-Ahead-of-Print July 3, 2009, DOI:10.2164/jandrol.109.007898
Journal of Andrology, Vol. 30, No. 6, November/December 2009
Copyright © American Society of Andrology
DOI: 10.2164/jandrol.109.007898

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
30/6/734    most recent
Author Manuscript (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Khattri, A.
Right arrow Articles by Thangaraj, K.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Khattri, A.
Right arrow Articles by Thangaraj, K.

APOB Gene Signal Peptide Deletion Polymorphism Is Not Associated With Infertility in Indian Men

ARUN KHATTRI*, RAJEEV K. PANDEY*, NALINI J. GUPTA{dagger}, BAIDYANATH CHAKRAVARTY{dagger}, MAMTA DEENADAYAL{ddagger}, LALJI SINGH* AND KUMARASAMY THANGARAJ*

From the * Centre for Cellular and Molecular Biology, Hyderabad, India; the {dagger} Institute of Reproductive Medicine, Kolkata, India; and the {ddagger} Infertility Institute and Research Centre, Hyderabad, India.

Correspondence to: Dr K. Thangaraj, Centre for Cellular and Molecular Biology, Uppal Rd, Hyderabad 500 007, India (e-mail: thangs{at}ccmb.res.in).



Abstract

Apolipoprotein B (APOB) plays a key role in lipoprotein metabolism and plasma lipid transport. It has been shown that about two-thirds of male mice heterozygous for ApoB were infertile. Moreover, a 3-codon deletion polymorphism (rs11279109) in the signal peptide region of the APOB gene has been shown to be a risk factor for infertility in Slovenian men, but its association with infertility in Indian men has not been evaluated to date. Hence, in the present study, we have genotyped this polymorphism in 545 Indian men, including 294 infertile and 251 fertile men. Our results show that the distribution of this deletion polymorphism was consistent with the Hardy-Weinberg equilibrium in both infertile and fertile men. No statistically significant difference was observed in the distribution of the APOB signal peptide deletion polymorphism between infertile and fertile men ({chi}2 = 0.156, P = .925 for genotypes; {chi}2 = 0.015, P = .903 for alleles). Moreover, no significant difference was observed when infertile and fertile men were categorized on the basis of presence (D/D and D/W genotypes) or absence (W/W genotypes) of deletion (odds ratio, 0.955; 95% confidence interval, 0.644–01.418; P = .820). Our study concludes that the APOB gene deletion polymorphism is not a risk factor for the development of infertility in Indian men.

     Key words: Spermatogenesis, apolipoprotein B






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2009 by The American Society of Andrology.