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Case Report

Sperm and Embryo Analysis in a Carrier of Supernumerary inv dup(15) Marker Chromosome

EVA ORACOVA^*,

PETRA MUSILOVA^*,

ROMAN RYBAR^*,

KATERINA VESELA

JIRI RUBES^*,

From the ^* Veterinary Research Institute and Repromeda, Brno, Czech Republic.

Correspondence to: Jiri Rubes, Department of Genetics and Reproduction, Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic (e-mail: rubes{at}vri.cz).

Abstract

We identified a small, paternally inherited, supernumerary marker chromosome, inv dup(15), in a phenotypically normal and normozoospermic male from a couple with reproductive problems. Sperm analysis by fluorescence in situ hybridization (FISH) showed that the marker was present in 26% of sperm nuclei. The disomy 15 was 10 times higher than in normal control donors. FISH analysis for aneuploidies of the other chromosomes showed an increase in nondisjunction of chromosome 21. We also examined 24 embryos by preimplantation genetic diagnosis, and 10 embryos (41.7%) contained the marker. This report provides information about inheritance of inv dup(15) from a male carrier.