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1 Departments of Physiology and
Biophysics, and Obstetrics and
Gynecology, Dalhousie University,
Halifax, Nova Scotia, Canada
The catecholamines isoproterenol, epinephrine, and
norepinephrine stimulated androgen production by
mouse interstitial cells in primary culture. The amount
of androgen produced in response to maximum stimulation with these amines was less than that produced
with maximum human chorionic gonadotropin stimulation, but produced an additive effect when combined
with a submaximal concentration of human chorionic
gonadotropin. The stimulatory effect of isoproterenol
could be blocked by the 
-receptor antagonist propranolol. Isoproterenol did not stimulate androgen production by either freshly isolated mouse interstitial cells or
whole decapsulated testes.
Key words: catecholamines, Leydig cells, androgens, cell culture
Submitted on July 27, 1981
Revised on October 12, 1981
Accepted on October 19, 1981
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