Journal of Andrology Testis Workshop 2009
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by GERRITY, M.
Right arrow Articles by FALVO, R. E.
Right arrow Search for Related Content
PubMed
Right arrow Articles by GERRITY, M.
Right arrow Articles by FALVO, R. E.
Journal of Andrology, Vol 3, Issue 4 221-226, Copyright © 1982 by The American Society of Andrology

The Physiologic Effects of Testosterone in Hydrogenated Soybean Oil Vehicle as Compared to Free Testosterone, Testosterone Propionate, and Testosterone Enanthate in a Conventional Oil Vehicle

M. GERRITY 1, M. FREUND 1, R. N. PETERSON 1, AND R. E. FALVO 1

1 Department of Physiology and School of Medicine, Southern Illinois University, Carbondale, Illinois

We have recently described a new technique that utilizes hydrogenated soybean oil (HSO) as the vehicle for the controlled and sustained release of testosterone (T) (Gerrity et al., 1981). The purpose of the present study was to compare the physiologic effects of this mode of T administration with those of the clinically used T preparations (free T; T propionate, TP; or T enanthate, TE) when administered in liquid soybean oil (LSO), a conventional vehicle. Castrated male rats were treated with 5 mg T in either HSO or LSO, or an equivalent amount of TP or TE in LSO. Groups of four animals were sacrificed 1, 3, 5, or 7 days after injection. Serum concentrations of T and luteinizing hormone (LH) and accessory gland weights (AGW) were determined.

The results of these experiments indicate that there is a difference in all three parameters of functional androgenicity when various testosterone preparations are administered. A single injection of free T in LSO was incapable of producing either a significant increase in AGWs, a sustained increase in serum concentrations of T, or suppression of the high serum concentrations of LH in the castrated rat. The same dose of free T administered in HSO produced a marked increase in serum concentrations of T and in AGW and a suppression of serum concentrations of LH. The difference in duration of action of T when administered in these two vehicles was dramatic. Whereas T was not detectable in the serum of rats five days after injection of T in LSO, serum concentrations of T in animals treated with T in HSO remained in the physiologic range throughout the period studied. TP produced an effect similar to that of T in LSO, and TE produced an effect similar to that of T in HSO.

This study also presents evidence that T esters such as TP or TE may not act at the level of the pituitary gland in the same manner as T itself. The order of potency in LH suppression is TE > T in HSO > TP > T in LSO. This potency in decreasing serum LH levels does not correlate with peak serum T levels.

     Key words: testosterone, hydrogenated soybean oil, conventional vehicle

Submitted on May 30, 1980
Revised on September 8, 1981
Accepted on September 28, 1981




This article has been cited by other articles:


Home page
 Drug Metab. Dispos.Home page
M. D. Anderson, S. M. Bandiera, T. K. H. Chang, and G. D. Bellward
Effect of Androgen Administration During Puberty on Hepatic CYP2C11, CYP3A, and CYP2A1 Expression in Adult Female Rats
Drug Metab. Dispos., October 1, 1998; 26(10): 1031 - 1038.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1982 by The American Society of Andrology.