Published-Ahead-of-Print July 17, 2008, DOI:10.2164/jandrol.107.004838
Journal of Andrology, Vol. 29, No. 6, November/December 2008
Copyright © American Society of Andrology
DOI: 10.2164/jandrol.107.004838
Effects of Testosterone on Antioxidant Systems in Male Secondary Hypogonadism
ANTONIO MANCINI*,
ERIKA LEONE*,
ROBERTO FESTA*,
GIUSEPPE GRANDE*,
ANDREA SILVESTRINI
,
LAURA DE MARINIS*,
ALFREDO PONTECORVI*,
GIULIO MAIRA
,
GIAN PAOLO LITTARRU
AND
ELISABETTA MEUCCI
From the * Chair of Endocrinology, the
Institute of Biochemistry and Clinical
Biochemistry, and the
Institute of
Neurosurgery, Catholic University of The Sacred Heart, Rome and the
Institute of Biochemistry, University
"Politecnico delle Marche," Ancona, Italy.
|
Correspondence to: Antonio Mancini, MD, Largo G. Vidari 7, 00135 Rome, Italy
(e-mail:
mancini.giac{at}mclink.it). |
Oxidative stress is involved both in metabolic syndrome and male
infertility. Hypogonadism is also associated with increased risk for
cardiovascular disease. To investigate the role of gonadal steroids in
systemic antioxidant regulation, we determined plasma CoenzymeQ10
(CoQ10) and total antioxidant capacity (TAC) in postsurgical
hypopituitaric patients. Twenty-six patients aged 28–55 years were
studied 6–12 months after surgery. CoQ10 levels were measured
by high-performance liquid chromatography and TAC by spectroscopy with the use
of the mioglobin-H2O2 system, which, in interacting with
chromogen 2,2I-azinobis-(3-ethylbenzothiazoline-6-sulfonate),
generates a radical after a latency time (LAG) that is proportional to
antioxidant content. Sixteen patients presented low testosterone values; in 10
patients hypogonadism was isolated, and in 6 patients hypothyroidism also was
present. CoQ10 levels were significantly lower in isolated
hypogonadism than in normogonadism. Testosterone treatment, performed in those
patients with isolated hypogonadism, induced a significant enhancement both in
CoQ10 level and LAG. CoQ10 and LAG values correlated
significantly, suggesting an interrelationship between different antioxidants.
Our data suggest that hypogonadism could represent a condition of oxidative
stress, in turn related with augmented cardiovascular risk.
Key words: Androgen, oxidative stress, coenzyme Q10, total antioxidant capacity
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Copyright © 2008 by The American Society of Andrology.