Journal of Andrology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Published-Ahead-of-Print July 17, 2008, DOI:10.2164/jandrol.107.004838
Journal of Andrology, Vol. 29, No. 6, November/December 2008
Copyright © American Society of Andrology
DOI: 10.2164/jandrol.107.004838

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
29/6/622    most recent
Author Manuscript (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mancini, A.
Right arrow Articles by Meucci, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mancini, A.
Right arrow Articles by Meucci, E.

Effects of Testosterone on Antioxidant Systems in Male Secondary Hypogonadism

ANTONIO MANCINI*, ERIKA LEONE*, ROBERTO FESTA*, GIUSEPPE GRANDE*, ANDREA SILVESTRINI{dagger}, LAURA DE MARINIS*, ALFREDO PONTECORVI*, GIULIO MAIRA{ddagger}, GIAN PAOLO LITTARRU§ AND ELISABETTA MEUCCI{dagger}

From the * Chair of Endocrinology, the {dagger} Institute of Biochemistry and Clinical Biochemistry, and the {ddagger} Institute of Neurosurgery, Catholic University of The Sacred Heart, Rome and the § Institute of Biochemistry, University "Politecnico delle Marche," Ancona, Italy.

Correspondence to: Antonio Mancini, MD, Largo G. Vidari 7, 00135 Rome, Italy (e-mail: mancini.giac{at}mclink.it).


Oxidative stress is involved both in metabolic syndrome and male infertility. Hypogonadism is also associated with increased risk for cardiovascular disease. To investigate the role of gonadal steroids in systemic antioxidant regulation, we determined plasma CoenzymeQ10 (CoQ10) and total antioxidant capacity (TAC) in postsurgical hypopituitaric patients. Twenty-six patients aged 28–55 years were studied 6–12 months after surgery. CoQ10 levels were measured by high-performance liquid chromatography and TAC by spectroscopy with the use of the mioglobin-H2O2 system, which, in interacting with chromogen 2,2I-azinobis-(3-ethylbenzothiazoline-6-sulfonate), generates a radical after a latency time (LAG) that is proportional to antioxidant content. Sixteen patients presented low testosterone values; in 10 patients hypogonadism was isolated, and in 6 patients hypothyroidism also was present. CoQ10 levels were significantly lower in isolated hypogonadism than in normogonadism. Testosterone treatment, performed in those patients with isolated hypogonadism, induced a significant enhancement both in CoQ10 level and LAG. CoQ10 and LAG values correlated significantly, suggesting an interrelationship between different antioxidants. Our data suggest that hypogonadism could represent a condition of oxidative stress, in turn related with augmented cardiovascular risk.

     Key words: Androgen, oxidative stress, coenzyme Q10, total antioxidant capacity




This article has been cited by other articles:


Home page
 Eur J EndocrinolHome page
Z. Hyde, P. E. Norman, L. Flicker, G. J. Hankey, K. A. McCaul, O. P. Almeida, S. A. P. Chubb, and B. B. Yeap
Elevated LH predicts ischaemic heart disease events in older men: the Health in Men Study
Eur. J. Endocrinol., April 1, 2011; 164(4): 569 - 577.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
A. Mancini, R. Festa, A. Silvestrini, N. Nicolotti, V. Di Donna, G. La Torre, A. Pontecorvi, and E. Meucci
Hormonal Regulation of Total Antioxidant Capacity in Seminal Plasma
J Androl, September 1, 2009; 30(5): 534 - 540.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by The American Society of Andrology.