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Immunohistochemical Detection of the Retinoid X Receptors , ß, and in Human Prostate

MARIA V. T. LOBO

From the Department of ^* Cell Biology and Genetics, University of Alcalá, 28871, Alcalá de Henares, Spain; and Molecular Oncology Laboratory, Hospital Ramón y Cajal, Madrid, Spain.

Correspondence to: Dr María I. Arenas, Department of Cell Biology and Genetics, University of Alcalá, 28871 Alcalá de Henares, Madrid, Spain (e-mail: misabel.arenas{at}uah.es).

The aim of this study was to evaluate the presence and distribution of retinoid X receptors (RXRs) , ß, and in normal, hyperplastic (nodular, basal cell, and atrophic hyperplasia), and carcinomatous human prostates in order to elucidate the relationship among these receptors and the onset and development of prostatic adenocarcinoma. RXR and RXR were immunodetected in all samples of normal, nodular, and basal cell hyperplasia, as well as carcinomatous prostates. In atrophic glands, the expression of both receptors was found in 22.5% of samples. Positive immunostaining for RXRß was observed in 53.3% of normal prostates, 100% of samples showed basal cell hyperplasia, and were negative in nodular and atrophic hyperplasia. In prostatic adenocarcinoma, only 3 of 25 samples (the 3 diagnosed as well-differentiated) were positive for RXRß. Results suggest that diminished RXRß expression might be related to prostate cancer progression and because the responsiveness to retinoic acid treatments depends on the expression of different receptors, it is important to study their expression before therapy.

     Key words: Immunohistochemistry, RxRs, prostate cancer

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